Domino is Grandma Emma’s black and white Kyi-Leo dog. He turns pink and green when Grandma tries a formula to clean the dog. Later, in Wishville, when he goes swimming in the blue lake, his coat changes to dark green and purple.

Domino is a mischievous dog, getting into messes and causing embarrassment to Grandma. He is also creative, wishing his dog pals to Wishville for a dog show. When Grandma and Alyssa leave Wishville, with no apparent way to return, Domino saves them by wishing them back.